ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will improve the level or effect of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Acute ergot toxicity characterised by vasospasm and tissue ischemia has been linked to coadministration of ritonavirberotralstat will improve the level or impact of ergotamine